Vitamin K2 (Pt 4): Matrix Gla Protein Activation (Summary)

Vitamin K2 (Pt 4): Matrix Gla Protein Activation (Summary)

This is just a quick update to help
connect some dots. The vitamin K2 story can be fairly confusing. In fact, you see
a lot of emotion, a lot of hype around it, maybe more so than the facts. This is
just a nice infographic that I found on the Internet, and it helps again
understand some of the connections. So there’s a protein called matrix gla
protein (MGP). It actually helps some of the activities which decrease calcium in
the artery wall. However… and that gets back to to some hormones which we won’t
cover right now. Basically, we want to get back up to the K2 story in order for MGP
gla… the matrix GLA protein to be active though it has to be carboxylated. In
order to be carboxylated, it has to… there has to be some K2 involved. You may
remember a recent video that I did basically out of one of the Journal
of the American College of Cardiology. It mentions that
gla protein and talks about carboxylation of that
protein matrix gammacarboxy glutamic acid. So in this article, what we
were talking about is decreasing carboxylation with the gamma carboxylation
enzyme. So again some difficult connections to make and I
think after we get some repetition on that and get it out there a few times
and just some simple messages like that, we’ll start to get the picture on what’s
the mechanism that’s causing so much excitement behind K2. Thanks for your
interest. My name is Ford Brewer. I started off as
an ER doc. I became very frustrated with the fact that most
things that bring people into the ER were preventable like heart attack and
stroke. I went to John Hopkins to get training and ended up running the
program there in prevention. There, I trained dozens of docs and again that
was three decades ago. Since then, I’ve trained thousands of docs
and even more importantly supervised those docs. And even most importantly
helped thousands of patients prevent things like heart attack and stroke.
Waiting for the disease and hoping for a cure for this kind of devastation
doesn’t work. Come to Louisville on November 8 and 9. We have a boot camp
type of environment for two days where you learn all the things that you didn’t
learn from your doc in terms of heart attack & stroke prevention. Things like
cardiovascular inflammation, how to detect it, how to measure it, things like
insulin resistance… the number one cause of inflammation, how to detect it, how to
measure it, how to stop it, how to manage it. You also get… you can get the labs
there for that event if you’d like and get a complete evaluation. In addition,
you get an arterial scan called a CIMT. To get the right one of those is fairly
difficult. So I’m looking forward to seeing you there. Thanks.



  • Radnally

    Useful information. Thanks

  • Akane Cortich

    So the common blood thinner warfarin actually inhibits the action of the K2 'fed' protein (whose role it seems, via paths, is to inhibit uncontrolled calcification.) and gives improper calcification and renal / artery damage. That was 2015. Wonder if Drs. know to maybe avoid proscribing warfarin to patients with kidney issues? ("…warfarin inhibits this function of MGP, which in turn, antagonizes the inhibitory role of MGP in the process of vascular calcification, resulting in arterial damage and a decline in renal function.")

  • Akane Cortich

    Somebody should teach these researchers to write readable english.

  • Uriel Wong


  • Akane Cortich

    My mother in law (96) has mild kidney issues, and on blood thinners. But at 96 I guess it isn't an issue.

  • Akane Cortich

    Luckily it was my job for some years in the past, to write the same type of garbled English in reports, just so nobody could understand the underlying truth.

  • Bart Robinson

    Looking forward to more Dr Brewer!

  • raffaele gagliano

    Dr. brewer, it is true that K2 removing calcium from arteries can be counterproductive as it destabilizes the underlying plaque ….. then what to do. Have you ever considered integrating K2 with serrapeptase? apparently it removes dead tissues like plaque ….. if it would work, ………… a fantastic solution ……? I would appreciate if you accepted my supposition. A greeting

  • Diamond Life201

    I went to my cardiologist heart clinic in Lansing MI, he didn't know what I was talking about Nore was there nothing or no one who could help me answer any of these questions. He told me he was going by basic standards. Wow!!!. These doctors are in partnership with the mayo clinic. You would think they were informed or updated about these sort of things. Very upsetting.

  • Diamond Life201

    I think no one know what the heck were talking about because major pharmaceutical companies are researching this as we speak and trying to come up with the next big million dollar pill, which they would charge a million dollars for however middle man nore poor man get any. Totally disgusting. GREED.

  • Matthew Alloy

    Excellent Podcast 🙂👍
    More info on k2 please

  • Mcgragor

    So are you taking K2? What kind, how much?

  • B.K. Teh

    can take k2+ D3 together with turmeric ?

  • jef jafaraga

    I have watched all 4 parts of your K2 videos and I really got more confused than I was before.
    You remind me of one of my teachers in college. Whenever we went to him to clarify a problem, ended up more confused. You made an unscientific remark at your 1st video about K2 removing the calcium and releasing the soft plaque and therefore causing hearth attack or stroke. You are an MD and I do value your opinion. At this point I really don't know what exactly is your position regarding taking K2 supplements or not. Also it is a good practice to summarize your talk in a simple and clear language at the end for a laymen like myself.

  • Ron Baker

    Thank you for your discussion on K2 I was taking K2 prior to a DVT in 2011 and four of my Doctors went ballistic over the that revelation. Am now on Xarelto and most of the supplements I had taken before. Do you share the same opinion of not taking K2 while on Xarelto or on any blood thinner if potentially susceptible to blood clots? Thanks.

  • Robin

    Will k2 decrease vessel calcification in patients on warfarin for AF? Are there drug interactions with K2 like beta blockers?

  • Ed Roy

    Dr Brewer, could you post a link to the infographic please, it would assist understanding the conversation👍

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