Vitamin K2 (Part 6): Osteocalcin & Diabetes – Another K2 Story?

Vitamin K2 (Part 6): Osteocalcin & Diabetes – Another K2 Story?

I’ve shared with you a couple of times. I
I used to ignore vitamin K2. I totally ignored it for a long time. Then
some viewers asked me to look into it. So I did I went straight to the
clinical trials and there’s just not much on clinical trials on K2 yet. You
know, maybe there will be, maybe there won’t be. But recently, I got interested
yet again in vitamin K2 and I’m gonna drop that discussion for just a second
and pick up an entirely different thread and see if you start to make the
connection here. And again, this… there may be a significant connection, maybe not. Let me just read some titles. “Reduced
serum concentrations of carboxylated and undercarboxylated osteocalcin are
associated with the risk of developing type 2 diabetes.” The next one, “Osteocalcin
is related to enhanced insulin secretion in gestational diabetes.”
The third one, “Association between serum osteocalcin and markers of metabolic
phenotypes.” And when you get deeper into the article, the metabolic phenotypes,
they’re talking about are for a look for mostly insulin resistance, diabetes.
So there’s osteocalcin. Ring any bells? Let’s talk about that in just a minute.
But first… but before we do I mean there’s article after article “Low
osteocalcin level is a risk factor for impaired glucose metabolism in a Chinese
population.” And it just over and over and over again, this is… these are not two or
three articles that I’ve just cherry picked out of the science. There’s
clearly an implication for glucose metabolism linked to osteocalcin. Now
wait a minute. I just… osteocalcin ring any bells yet
for you? And to link it back to that first topic i brought up about vitamin
K2, remember we were talking about the mechanism how can vitamin K2 impact both
both soft tissue like artery walls and hard tissue bones. Well it has to do with
carboxylation. That’s undercarboxylated MGP and undercarboxylated osteocalcin with MGP matrix gla protein (MGP). That once you carboxylate
MGP, you can inhibit vascular calcification with the bone. You actually
you can increase calcification of the bone by carboxylating osteocalcin,
activating it. You can. Also, what most people don’t
don’t get into even the K2 Bureaus is that you can do… you can go
both ways in terms of calcium and bone. It helps to activate both osteoblasts
(which build or deposit bone calcium and bone) and osteoclasts (which cut calcium
or and/or protein out of the bone). But again, K2 is very involved in activation
of the enzymes which are involved, in turn, with managing calcium. So let’s go
one step further. As I mentioned, they just gives you the topic that I
covered just now. Osteoblasts, “B,” build. And osteoclast, “C,” cut. Both of
them have to do very much to do with bone mass. That’s how our body continues
to customize our bone mass to our current needs and again it’s MK7 is
suppresses on the osteoclast side and it stimulates on the osteoblasts side. So
very interesting, right? But wait a minute. Was this about K2 or was this about
insulin resistance? So in humans, osteocalcin levels are inversely
correlated with multiple various variables of type 2 diabetes such as
glucose intolerance and insulin resistance. Decreased levels of
osteocalcin have also been correlated with premature or myocardial infarction
and coronary heart disease. So here is a graph, looks kind of scatter shot at
first, but as you begin to notice, you don’t have a lot of dots down here and a
lot of dots up there. There is a fairly reasonable correlation. What is it?
Hemoglobin A1c on the vertical axis and osteocalcin on the horizontal axis so
it’s interesting I haven’t heard a lot of discussion about K2 and whether
there’s any at the end of the day whether there’s any K2 relationship with
insulin resistance and that’s one of the things that’s just really intriguing to
me right now. But as I said, there’s no question that
I’ll say that K2 is related to osteocalcin, and
osteocalcin is in turn related to insulin resistance. Here’s a visual on it.
Osteocalcin increases both adiponectin, adipocytes, fat cells, and proliferation
of beta cells, and increased insulin, and increased insulin sensitivity, leading to
improve glucose handling and lower fat mass. So what’s going on here? Uh heck if
I know but it’s a very interesting set of
relationships, isn’t it? If you’ve made it this far, thanks for your interest.



  • farrokh farr

    not much detail on k2 for my calcified arteries. thank you good doctor

  • Paul Yac

    Good morning Doc, thanks for sharing, so I can and still take my K2 & mk-7!

  • Aspen N

    Unfortunately metabolic syndrome is a dearrangement that makes everything changed in metabolism. If we start looking and finding correlations with every chemical and get excited every time we may get tired from it really quick. Some find correlations with low anything and start ingesting things hoping for cure. Good luck.

  • gcam474

    Another five star vid. Thank you sir. Very interesting. Looking forward to any further findings on this relationship. I didn’t know that K2 is osteoclast inhibitory. This is exactly why we don’t like pharmaceuticals like Actonel, Fosomax and other bisphosphonates. Read; spontaneous fracture risk. Very interesting but I wouldn’t stop my K2 based on this, much less ever go near a bisphosphonate.
    Edit: Sorry, thought I should add that normal osteoclast activity is thought to support elimination of old or compromised calcium while osteoblast activity deposits new calcium. The theory of damage promoted by bisphosphonates is that they work only to inhibit osteoclast activity. This allows bone density to increase but does not increase bone strength.
    Yeah, sorry the comment went on a tangent to your original revelations. Great stuff. Thank you.

  • Sapele Steve

    Very interesting Dr. Brewer! I wonder if K2 has any effect on how Osteoblast lay down Ca++ in bone? If it does have a beneficial effect, then perhaps post menopausal women should be taking this supplement to prevent (or maybe reverse) Osteoperosis? Your thoughts? Thanks

  • Matthew Alloy

    Excellent Podcast 🙂👍

  • D Johnson

    I just had my CIMT in Anaheim by Cardio Risk. Anxious to get back the results.

  • 147DegreesWest

    Great video doc!! It is a very interesting connection. My mom had osteoporosis and she died from congestive heart failure/ calcified aortic artery. There is no doubt in my mind from watching lost friends and family that there is some kind of relationship between bone health and vascular health – and I suspect k2 mk7 is involved in that relationship

  • Radnally

    Thanks. Great info

  • ron Howell

    Dr. brewer I'm diabetic two since early forties. I had open heart surgery about 8 years ago, I was cardio cathed after passing my stress test with flying colors. I had two stents placed upon catherization broke three balloons trying to place a stent , had hard calcium # 3 blocks 95 % block and A another artery 50% block I had ten total places in my coranary arteries with blockages. two weeks later I had open heart surgery because I was Diabetic. so when Heard about the comment from your listener who had knee replacement I researched and started taking vit k-2.
    two years ago.I was in the hospital in chf, got out quit taking the stations, and other drugs, went on the ketogenic diet and I went from 288 lbs to 194.6 pounds in about a year and 3 months. hgbaic went from 10.6 to 6. 3. do you think the vit k-2 is having a neg. effect on my diabetes. Have I lenghtend my life by making theses changes.

  • BadBeat

    You might be interested in this study: "Effect of vitamin K2 on type 2 diabetes mellitus: A review"

  • MrJoeyBoombotz

    My understanding is that K2, when taken taken with D3, will deposit the calcium in the bone. I'm not sure that it removes calcified plaque from arteries but I'm not worried that much about the calcium I already have in my arteries (copius, 3,277 on coronary MSCT in 2006) as much as stopping its progression and the inflammation to the soft plaque, which is the danger.

  • Loretta Dillon-Ham

    I’d like to understand this topic more.

    It sounds complex and a little confusing but I am up for learning and getting my head around this topic. I want to be able to coach/support people with their health choices. I’d definitely like to learn more on this.

  • Loretta Dillon-Ham

    1:14 (to 1:22) enhanced insulin secretion
    Is this saying a higher amount of insulin is released by the pancreas which would be identified/recognised as a diabetic insulin pattern?

  • Loretta Dillon-Ham

    Dr B, I have so many questions ….
    1:28 “metabolic phenotypes” is this referring to ApoE2/3/4 ?

  • moma jugy

    I so appreciate your focus on K2 as of late. I added it in last year trying to beat back diabetes. BMI at 24 with blood pressure at 120/70. Your help is always considered a blessing.

  • Neal Paige

    Is it ok to take K2-D3 if your taking Plavix ?

  • C Moses

    What about K2 and aspirin? I've read that K2 is a bit of a clotter and aspirin a thinner. I'm on low dose aspirin … would K2 counteract this and if so would that increase my risk for heart attack/stroke?

  • nothing1099

    Getting vitamin K2 from organic milk from grass fed cows helps keep the pancreas functioning properly and improves insulin response to better moderate blood sugar levels?
    Organic milk from grass fed cows also has CLA, which helps fat cells release fat thus moderating fat mass.
    Economists say you are supposed to be increasing financial pressure on farmers to lower their costs, which leads to using antibiotics, hormones, grains, and storing hay outside.

  • Agus Dwiono

    Dr Brewer, can I take vit k2 to stop or reverse artery calcification while on aspirin cardio100mg and brilinta90mg. Pls advise. Thank you.

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