Vitamin K2 (Part 3):  Prediabetes & Inflammation – Pleiotropic Roles

Vitamin K2 (Part 3): Prediabetes & Inflammation – Pleiotropic Roles

So with council with K2, there appears to
be a role with calcium, a role with insulin resistance, and a role with
inflammation. One of our recently released videos on
K2 and artery calcification got a lot of attention. It wasn’t all the good count. I
ended up saying I hope this wasn’t too confusing because I went around a couple
of times. Bottom line was it was confusing and I think it was too
confusing so I’m gonna try to clear up a couple of things in this video. Now in
order to clear those up though, I think we have to start getting into an issue…
maybe a bigger issue of biology and that is what we call pleiotropic roles. What
our pleiotropic roles? We’ll talk about them in just a minute.
But short version is it’s multiple roles from the same thing. Now let’s go back
and understand pleiotropics just a little bit more. Pleiotropic, if you look
it up on Google, producing or having multiple effects. One of the key places
that we see this in medicine is in genetics. We have pleiotropic genes for
example the Marfan’s gene. It creates long fingers of thin body, misshapen
chest, mitral valve problems, joint problems, eye problems… a lot of things
that may seem to be unrelated. And until you start going deeper now, we all see
this. You don’t have to be a physician or a geneticist or any of that. You all see
that see this when you take simple medications even including
over-the-counter medications. Let’s go back to something most of us have known.
Many of us most of us have probably taken a good old-fashioned Benadryl, an
antihistamine. It’s given for anti-nausea. It’s given for sleep. It’s taken for anti-allergy medicine. Of course, that’s the most common use. It’s also taken for itch
in anti-itching. So again, multiple uses for that antihistamine which and until
you begin to understand things a little bit better may seem unrelated. Well with
drugs, we often call these pleiotropic effects as “side effects.”
Now here’s the other thing to think about. As I said, these all… these
different effects may seem unrelated until you go a little bit deeper. For
example, with Benadryl, what’s sleep got to do with anti-allergy and what’s all
that got to do with itching. All of that basically has to do with the thing
called histamine. And this is an antihistamine. When it blocks histamine,
it starts having all of these different effects – pleomorphic effects. With that
Marfan’s gene… Marfan’s… the Marfan’s gene changes the
way the body makes connective tissue. Well places where connective tissue is a
big deal in terms of the shape of the chest, how long fingers, our eyes, the
aorta… which can kill Marfan patients at age 30… mitral valve… all of those things
have to do with the Marfan gene impact on connective tissue. So we talked about
pleiotropic. $5 word to basically mean multiple uses
or multiple roles. Let’s talk for a minute about the rest of this channel.
This is not the first time we’ve mentioned pleiotropics. For example,
we’ve talked about pleiotropics with statins multiple times. Remember most of
the rest of the medical community prescribes statins for impact on
cholesterol. I don’t usually… when I do recommend use of statins it has to
do more with the pleiotropic mechanism or what other people might consider the
“side effect”… the impact of statins on cardiovascular inflammation. There’s
another place that I’ve mentioned a few times but not that often unless you’ve
gone into some of our cognitive decline our Alzheimer’s videos and it has to do
with insulin. Insulin has significantly pleiotropic effects. We talked about insulin
all the time on this channel but it’s mostly the impact of insulin in the rest
of the body. If you inject insulin into the nose, it will go past the blood-brain
barrier. And once insulin goes past the blood-brain
barrier and gets into the brain, it has a whole different set of mechanisms. Most
of them are revolving around the hippocampus and the biological
biochemical mechanisms of memory formation. So again bios you can be a
little bit complicated medicine can be complicating but you know what we need
to understand some of these things if we’re gonna do the best job for
preventing heart attack stroke and obviously cognitive decline. So back to
heart attack and stroke and K2. So what are some of these different mechanisms
for K2? Well, first of all, K2 carboxylates a couple of enzymes that are very
important in several processes here. One was that first enzyme that I that I
mentioned in this maybe botched presentation on artery
calcification… MGP… matrix gla protein. The other enzyme that K2 carboxylates
is osteocalcin. Now we’re starting to get a little bit technical here. I’m gonna
jump back up to about 30,000 feet and say, “Look, you see it in two or three
places here. It activates those enzymes.” Those enzymes we know have a lot to do
with calcification of the bone and calcification of other tissue like
plaque. Look at the bottom line. The bottom line here: they also impact plasma
glucose and insulin sensitivity on the way. There there’s an impact on
inflammation and women and it impacts the markers that we’ve talked about
multiple times again on this channel involving inflammation. AMPK. PPAR alpha.
So again K2 has few more effects and impacts
and roles than think we just don’t completely understand yet. So another way
again of looking at it is that this is vitamin K and this this involves both K1
and K2. It involves anti- inflammatory effect, regulation of adipokine,
lipid-lowering effect, calcium effect, insulin sensitivity.. affect lots
of impact. There. Lots of different roles. And again if you’ve made it this far, I
appreciate it. Thanks. So you’ve been asking about it when’s the CIMT access tour.
Starting Anaheim LA September 28th David Meinz will be there with
some with a CIMT tech. It’s about 250 bucks for the whole afternoon plus the
CIMT plus the reading on the CIMT. If you have further interest, you can
sign up at CardioRisk.US/HealthyLife.



  • Max Kesik

    Is it beneficial to take k2 supplement as a healthy individual?

  • Gaudenz Gaudenz

    sorry, i didnt get/understand it (once again) πŸ˜‘…. like nearly always; WHATS THE MESSAGE PLEASE

  • Ron Wells

    K2 helped my joints alot…

  • Nancy Debosek

    I feel like I am asking the world's dumbest question. How does Vitamin K2 effect inflammation, cognition, and the other things listed in the video? Positively or negatively?

  • Blankname

    For those who don't understand: K2 has multiple effects, it doesn't just remove/regulate calcium. K1 and K2 both effect anti-inflammatory factors within the body, k2 lowers Total Cholesterol and Triglycerides, effects Grehlin (the thing that signals hunger) and leptin (the thing that stops hunger) and reduces plasma glucose within the body and INCREASES INSULIN SENSITIVITY.

    From my guess, with both the liver and muscle it signals an increase in AMPK which is used for muscle growth/increases cellular metabolism.

    If there's one thing to get from what what Dr. Brewer is trying to say is that k2 isn't as important for calcification as it is for it's potential insulin sensitivity benefits, the whole "K2 helps with calcium" might even stem from the fact that inflammation and insulin sensitivity tend to go hand in hand and increased arterial inflammation causes ruptures which cause plaque build up, so it's not surprising that there's potential relations and benefits.

  • Paul Yac

    Doc you didn't answer the question! Does K2 supplement improve the health of an average person?

  • Howard Seth

    Looking forward to Part 4 on K2. Seems important – Who should take it? and how much? Which forms of K2?

  • charles marriage

    K2 concerns various menaquinones, could this be the cause of the pleiotropisms. I used to ferment natto myself and various other chemicals notably were produced (eg Nattokinase). Were these conscientiously removed ?

  • Bart Robinson

    I just simply wish we knew for sure if K2 is beneficial for someone on statins with a high calcification score. I was taking it for a couple years but stopped. Thinking about starting again but I don't want to waste my money because it's fairly pricey. The more I try to learn it seems the more confused I get with all the different experts opinions and approaches……

  • Aaron Ho

    Effect how?! Good or bad?!

  • Marilynn Smith

    I asked the PA at the Cardiologist office about taking K2, since I had a heart attack in March. She said, absolutely not, since you are on a blood thinner and a statin. Of course, she also doesn’t believe in testing for PLa2, nor MACR, nor hsCRP, nor is she concerned about Insulin resistance, I think I need to find a new Cardiologist in the Phoenix area.

  • Nick Filippidis

    Doc when you mention K2 you are mean K2 in form of MK4, MK7 or both?

  • John InPhilly

    Well if your taking it Doc, that's good enough for me. Thanks always for everything.

  • At Rob

    Thank you Doctor, very good 3 word responses. Keep up the excellent research!

  • Sylvia Klages

    Dude! I just looked up Marfans Syndrome and all the effects. Every thing on the list is in me: Skinny, long limbs and digits, scoliosis, concave chest, depressed sternum, high palate, freaky aortic and mitral valves……That's me! Wonder why my doctors never told me, Maybe we could have done something about it long ago. Dang it. Sorry, I'm just venting. Thank you for the info, Doc..

  • Matthew Alloy

    Excellent information πŸ™‚πŸ‘

  • Rc Car guy

    Do you have any suggestions I have thalassemia minor which is a low red blood cell count I am not anemic but I also realize I'm not going to be a long-distance runner or someone who exercises extremely hard as the amount of oxygen going to my brain due to the low blood cell count could eventually hurt me if I pushed it. Do you have any recommendations on someone that has thalassemia minor

  • Charles Brown

    Can you take K2 while taking Zarelto?

  • Alien On a Bike

    What's the pleiotropic impact of insulin that non-diabetic body builders use insulin for? Is it for muscle growth or recovery or something else and how does it work? Don't worry, I'm not planning on injecting myself with insulin or anything else body builders use. My 88 year old father-in-law suffers from rapid cognitive decline – should I ask a doctor to inject some insulin into his nose? The problem is that he thinks he's got a great memory and thinks that other people think he's about 50. He looks 88 though (the only youthful feature about him is a full head of hair) and in my non-professional opinion is suffering from dementia and severe cognitive decline 😬

  • Dave King

    Watched all the videos you have done and still not sure if it helps atherosclerosis by reducing calcium build up or if it puts one at risk by removing stabilising calcium? You seem to suggest both in different videos.

  • Janet Lopez

    I just saw your coming to my hometown Louisville, KY. Unfortunately I can't afford it, do you happen to need volunteers for this so I can see some of the event?

  • Marilyn Harris

    WOW!! Thanks for posting this, Dr. B.! I've been taking K2 for a while to ease the inflammation and pain of varicose veins, and it appears to be helping! Good to know it's helping other stuff!

  • Parker Reed

    Dr. Brewer – As always, thanks for your wonderfully informative videos. If I could share: I've got a very high calcium score…started researching the issue and stumbled across books like Track Your Plaque (Dr. Davis) along with papers by Dr. Davis which discuss the reversal of coronary calcification. Along come your videos and based on this information, I continue to find — on PubMed, etc. — paper after paper that point to to insulin resistance as the key factor in coronary calcification.

    Further, from my understanding of the literature unless you reverse your insulin resistance and get your insulin levels under control, Vitamin K2 will provide minimal if any benefits (based on my understanding of all of this literature).

    Any of that sound right? this point, I'm about ready to write my own book. πŸ™‚

  • Steve T

    Enjoy all your videos. I might throw out to anyone interested that natto, a fermented soy bean, is a natural source of K2. Natto may be hard to find in many areas of the U.S., but I have found that most sushi restaurants offer natto rolls, I try to find a natural sources for all nutrients possible: berries and citrus for vitamin C, greens for K1 , A and folate, etc. The additional benefit is other micro nutrients that may be in the food. Thanks again Dr. Brewer.

  • radiojoehead

    K2 K2mk7 overcalcifies arteries?!! A comment below

    Is better take 500-800 micrograms to try remove as much calcium from arteries and soft tissues take 500-800 micrograms?? Or is 200 micrograms k2mk7 most body use safely per day??

    Is risk high taking k2mk7 supplement daily of destabilizing plaque that IS stabilized by calcium??

    Tough one since calcium in arteries dangerous??
    But destabilizing plaque held together by calcium seems dangerous too!

    Nattokinase dissolves blood clots safely
    Life extension has article. Your thoughts nattokinase
    1980 sumi discovered nattokinase dissolves blood clots

  • Julian Choque

    i appreciate those seconds of pure info at the beggining, keep up the good!! thanks

  • Bambi Able

    Not too technical at all…..I have been taking Vitamin K-2 for several years. In general, I feel better then I did two years ago.



  • Mike Sydney

    thank you, much better.

  • Ring Spanner

    Keep up the good work Doc !

  • orah ruth Kamienny

    Hi Doc I commented on your last video on K2 before I heard this one. I hope you go back and read it. The general public and the scientists need to know that K2 has several forms functioning differently in different tissues, sometimes on the same enzyme. To answer questions we need specificity.
    PS I'm not naming names but a certain Doc on internet criticized the idea of taking Metformin for insulin resistance "why take a medicine if you don't have the disease it treats" the Stupidity out there is unbelievable! Thank you for being a light in the dark. You have made my life much easier cause I safely rely on your info instead of spending much time researching on my own. If you want references for what I stated I'll dig them up. PSPS I saw your earliest videos on K2 and quietly disagreed with you; kept taking my MK7 and MK4.

  • Please ForgiveMyInsanity

    I am trying to figure out how to get my Mom on Niacin because that seems to be working well for you Dr. Brewer – but she is on Plavix for her new stents and I can't get a straight answer from the doctors.

    Do you have any idea if there's a way for the doctor to get her on Niacin with all the other meds she is on? Or is she basically gonna have to wait the 6 months to a year to get off the Plavix?

    It's just that her cholesterol is super bad and so is her % of blockage and so I figured the sooner she could get on Niacin the better – but she's so worried about it interfering with her other meds that she wont take it unless her doctor says it's okay – and her doctors not saying anything about it aside from "I can't recommend it" basically.

    She also takes MSM for arthritis and he's giving her the run-around about that as well…and if she doesn't get back on her MSM she's gonna start having Arthritis symptoms again and that's gonna make her heart even worse.

  • ari ari

    Amazing topic.. Thank you so much πŸ™πŸ™πŸ™

  • Shanza Shai

    But k2 thicken the blood.

  • xxx xxx

    Dr. Brewer, what dosage are you talking about for MK-7 ? Above 400 MCG ?

  • kayakutah

    As I understand it, so far:
    Carboxylated OC is good.
    In order to get Carboxylated OC, you need vitamin K2.
    The jury is still out as to whether or not there are other things that happen in the body, when you take vitamin K2 that may or may not be good.
    You don't seem to suggest that there are known bad side effects to taking K2, but it's possible there are.
    Is that about right?

  • Edward Ingram

    You say insulin "affects" memory, but you don't say positively or negatively.

  • SunRise SunRise

    Well so all together take K2 or not ?

  • Mark Stolzberg

    Have you critiqued the Rotterdam study in your videos? I read it a while ago and believe that they found a significantly reduced death rate and less calcified arteries after three years of 180 mcg of K-2 Mk-7. Any thoughts on this study that you could share with us?

  • Rc1

    I don't know but l'm still confused does help k2 yes o no

  • teddlespaw

    Came of statins in June after 10 years, taking Niacin, Lechitin and zerchol. My blood sugars where constantly high 6s, high 5s since coming of statins….that cannot be a coincedence

  • livey oone

    What are the dangers of taking K2? What if you only get it via sauerkraut?

  • Alba Solorzano

    Sorry doc. But after your video I'm more confused than informed…

  • kidpoker007

    I thought I saw a video where you recommend a vitamin k supplement?

  • iramoleramo

    Please Be a bit more clear Dr.
    What side are you ?
    Statines solution side or K2 solution side.???
    Statines side is the Bigfarma the bigMafia….

  • Lily Stonne

    I have been eating natto for a year. I believe that it is the safest and cheapest way of getting K2. I eat it as part of my breakfast 3 times a week. I believe that it has kept me off fosomax. My GP gives me a break from fosomax whenever the bone density test shows an improvement, then after 2 years another test is done and I have to go back on. I have been off fosomax for 3 years now with no mention of going back on, so I attribute this to the natto. I don’t like the taste and texture of natto but I eat it half-frozen and with vinegar and soy sauce to reduce the unpleasantness. I also add some sauerkraut or kimchi to mask the taste. A small price to pay to avoid taking fosomax.

  • Tall Inthesaddle

    Check out YT vids about K2 and D3 by Kate Rheaume-Blue.

  • Daniel Kleinmeier

    Look at the docs face… he’s well taken care of by his diet … and K2…

  • RRubi. ruboino

    I really love and enjoy the way Dr Brewer explains everything on his videos. Am getting all the tests he recommends done. To be on the healthy side of life it's mostly prevention with knowledge. Just picture going away with your family on a long vac trip…aren't you always checking your tires air pressure gas tank fuel lever water temp and so on?…no diference with our own bodies. Keep it right,keep it healthy, live well, its worth it all day long,….isn't it?
    Thanks doc.πŸ‘

  • Demenyi Robert

    If I take supplement K2 I can drink it with water or I need fat to absorb it well?

  • Adan Arceo

    Thank you very much Dr Brewer for giving us this valuable information at no cost, God bless you and your family and happy holidays…

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