Dr. Benjamin Bikman – ‘Insulin vs. Glucagon: The relevance of dietary protein’

Dr. Benjamin Bikman – ‘Insulin vs. Glucagon: The relevance of dietary protein’



  • Linda Mcmurry

    So how much carbs ,is to much

  • inoebene

    can we build muscle with ketegenic diet?

  • fiveshorts

    Simple question: is animal protein the only viable source in this scenario? It seems to be the assumption here, yet in these compromised times, consuming good quality red meat is not as easy or as safe as it used to be. Antibiotics, hormones, added sugars…

    Feeding a family with wholefoods grass-finished bison would cost $150 a day in protein alone.

    I would love to know whether protein supplements etc have a place in this paradigm (purely to satisfy the suggested protein intake, not as a source of the fat aspect etc)

    Many thanks

  • Spicy Artisan Hipster Salami

    Some folks are just fantastic speakers… well done, great work

  • Nancy Trimble

    Where is the subscribe button

  • MrAutospec

    T H A N K Y O U !!!!!!!!!!!!!!!!!!!!

  • Jule Kelly

    Outstanding video. Very helpful… I better understand the role of insulin and Ketosis. Glucagon was the missing element for me Being T2D. My focus is reducing insulin levels and becoming insulin sensitive.

  • ClickToPreview

    That was an EXCELLENT presentation Ben. I hope this gets spread like wildfire.

  • Evangeline Munda

    Oh my! I feel so elated ! Thank you so much Dr. Benjamin Bikman for your explanation. Such an eye opener.

  • Trevor Folgering - The Keto Solution

    This was an AMAZING talk! Thank you Dr. Bikman, for clarifying this very confusing subject for many! well done!

  • Roy Walker

    Eggs cooked in butter perfect food , high fat, high protein.

  • Muse It Up

    The importance of this talk cannot be understated. It really puts the carnivore diet's success into perspective. low carb, high carnitine, continued insulin sensitivity despite high protein intake. Awesome

  • La Vida Moderna de Julia

    I'm inlove

  • Stephen David Rathburn

    I've watched this three times and learn more every time. I am so thankful to know that Dr. Bikman teaches Med. Students. There's still a glimmer of hope for the medical field in the future !!!😊

  • Ken Chapel

    any phd or doctor posting videos and giving amounts of protein people need to eat each day better have some good insurance ……what you guys are doing is the equivalent of a psychiatrist giving an analysis of someone they have never met…..

  • Ty Wade

    "you'd be hard pressed to find a mammalian digestive system that as similar to human's as a k-9's"

    Bro, did you skip biology 101 and 102 in undergrad? Feed corn and potatoes to a dog for 10 days and see what happens.

  • Campa LTD

    Does this make the case for a carnivore lifestyle. Or a carnivore diet supplemented with quality fats.

  • pgreen6840

    Anybody think he looks like the lead singer for R.E.M. ? Cognitive Dissonance:)

  • Alexander Brandt

    Why doesn't he like fasting? What are these 'potentially deleterious consequences' he's referring to?
    Aside from refeeding syndrome, that is.

  • Dave Andrews

    Thanks Doc for all you do. Super relevant to my lifestyle.

  • Asura Khan

    Protein and fat=Whole eggs !

  • Tamzyn Murphy

    Does anyone know whether this holds true in T2D?

  • Sheila Collins

    I found this one article on the necessity of glucose for brain functioning. I'm unsure about whether or not it "proves" anything though. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900881/

  • Charonne Karringten

    Can you just have a couple of tablespoons of fat on a water fast. If it rise our insulin. Does the body really digest the fat. When it’s mtc oil

  • Nikita Dolan

    Okay, this is awesome news, but I noticed it was implied that glucugon has no effect on muscle at all, does this means no gains can be made on strict no refeed low carb/keto?

  • VoodooShelby

    FANTASTIC !!!!!!!!

  • Littlelady Lake

    Please add WFPB to your studies. We need all sorts of this data

  • Stef Diaz Diaz

    Yeah but what about poison ( secondary plant metabolites) in those low insulinogenic veggies? I preffer to eat white sugar!!

  • Akane Cortich

    I might also add there was a lecture that noted that the ketogenic diet assisted those in cachexia because of cancer, which is an inflammatory condition that inhibited muscle renewal.

  • Der Saa

    I think he has 10% more brain than we have… You can even see it…

  • john schlesinger

    Most informative and well presented.

  • CommandereON

    This video was fantastic! Fasting + Protein (to break out of the fast) + L Carnitine = get thinner

  • Flygande Potatis

    Healthy Bill Burr

  • Alper88

    So what's the conclusion? Does this mean I don't have to worry about insulin spikes if I eat a lot of protein with zero carbs and a little fat? I was on the Keto diet and now the Carnivore diet, but recently instead of losing more weight I'm starting to gain weight again. Someone adviced me to go higher protein and lower fat by eating leaner cuts of meat. Any thoughts?

  • James Haggenmiller

    Love Dr. Bikman… I can also appreciate that he came to this study/conclusion in good faith.

  • Sylvia King


  • Jai Prateek

    16:49 the smile on a fasted state. Take the message. My brain is on ketones.

  • SouthernRebel

    Doesn't this suggest that, theoretically, a low-carb diet could actually RAISE blood sugar levels, due to the effect of glucagon in the liver?? Especially for someone who's diabetic?

  • David Risner

    Are there long-term studies that prove eating this way reverses heart disease? If not, then I may stick with the whole-food, plant-based diet that did reverse MY heart disease (and TYPE 2 diabetes, and high blood pressure and arthritis, and…I could go on). Seriously, I am waiting for the peer-reviewed studies to come out that prove the consumption of all that saturated animal fat will help you live longer, reverse chronic disease, etc.

  • KenDBerryMD

    This is an amazing lecture. Everyone who eats LowCarb/Keto should watch, comment and share!

  • jonas farias

    does it mean that when doing keto we do not need to keep our proteins at 25% or our macro?? is it actually raising the glucagon level, plus promoting catabolic effects on adiposytes and liver?

  • J&S Electronics

    Woa, watching this a second time I caught an error in his presentation. @21:00 he shows the Insulin arrow getting bigger and the corresponding I/G ratio goes from 4 to 70. Ok, that's consistent.

    On the other side, he shows the Glucagon arrow getting much bigger, but says the I/G ratio stays at 1.3. Why no change when the Glucagon arrow gets so much bigger? Hmmm?

  • CrumbleLives

    I'm a bit confused with the concept of a SAD spiking the ratio by x70 when SAD presumably would include protein? Also curious about the impact of nutrient timing. And thirdly, what is the optimal way to build muscle to tone your body while adopting a keto diet?

  • 19hoggy66

    Your comment at 31:46 re low carb, low protein, HIGH Fat got laughed at, can I just say THANK YOU, the reasons you gave why some people have to do this WOW light bulb moment. I'd just been having hypo's hmm researched Hyperinsulinemia WOW I can lay claim to all it's symptoms -Dr Joseph Kraft informative. A confirmed Carnivore [I developed T2 d n 14.5 yrs of Atkins] I'm virtually vegetarian, now lost 65lbs normal blood glucose all down to eating lower protein [WHO guidelines] & Dr Fung's blogs. 20lbs to my celebratory steak dinner! Hopefully when at ideal weight I will break the insulin resistance/weight issue once and for all and protein will be the first macro I increase to maintain!

  • Timlagor

    He keeps saying things like 'it's because the body needs gluconeogenesis on the low-carb diet because otherwise …'
    Wish he'd be more careful about language: that's NOT WHY the insulin stays low: it's just (presumed to be) why people in whom it stays low were evolutionarily selected. The REASON for the phenomenon is going to be biochemical and probably really really REALLY useful to find out but it's not because otherwise you would die: the biochemistry doesn't know that!

  • Diego alberto Mejia

    Amazing lecture, I’ve never heard this approach before, even in my medical school years.- thank you 🙏

  • Corwyn Warwaruk

    Amazing video. Thank you it all the great information

  • molehead89

    This is great information!! As a Type 2 diabetic I have witnessed how too much protein can be the cause of rise in glucose. This will definitely encourage me to not short myself on the protein I should be eating! One thing that is not addressed in this subject matter is there is a difference in how different types of protein can cause elevated insulin response. For instance lean meats vs eating fatty meats. Ground beef causes higher insulin response than a fatty steak. Look up "Insulin Index chart", this will give you an idea of how foods raise insulin, and it goes into covering how different proteins affect the increase of insulin. Also remember that every time you eat you cause insulin to be released, so if you are a diabetic, then eating less meals should be considered!

  • CiPoint

    Very interesting science. Have I understood it correctly? When you are on a ketogenic diet you shouldn't fear protein shakes after your workout because they won't spike your I/G ration? Is that correct?

  • hamstersniffer

    Glad I've been following common sense about protein!
    I always reasoned that if ancient man kills a wildebeest he eats it, muscle, fat and all. That's a lot of protein. That's what our body and brain are built around, eating all the fat and muscle protein together. Thank you Dr. BB for confirming what seems logical.

  • Jose Peralta

    Standard American Diet, aka SAD!

  • Oscar Lohens

    Benjamin "I submit" Bikman

  • erquy funke

    does anyone know to answer my question? if i eat 70 gr carbs throughout the day but the 50 gr are after work out(dumbells, free weights) is this a reason not to be in ketosis or after working out you need carbs for glycogen therefore is kind of ok? 50 gr of carbs are in my protein-creatine formula.

  • Metqa

    I'd always been told that as you get older you need LESS Protein overall, and fewer calories from protein and fat to stay healthy. Become fruititarian and live forever. Be vegan and run marathons as a centurian,..centarian,? centenarians? Centuryboy? If my body is worse at healing seems like it should need more , not less protein. But nobody listens to you if you don't have letters after your name. Thankfully for me and my own reputation, Bikman does.

  • Emma Samara

    Hmm, so would supplementing with L-Carnitine, in conjunction with One Meal A Day (O.M.A.D) Keto Style and a caloric deficit, accelerate fat loss?

  • Sheeno101

    At 10:45, Dr Bikman (and the slide) indicate that glucagon plummeted in response to the alanine infusion. But from the graph, it looks to me that it spiked in a similar way to insulin, at least initially. Although it seems to be a bit lower following the spike than before, that only applies to the first infusion, and not the second. Either way, I certainly can't see any decreases as radical as 45 pg, as written on the slide. Can anybody help to show me what I'm missing here?

  • Hubert Bonisseur de la Batte de Baseball

    Outstanding presentation! Truly scientific and humble job of trying to untangle the complexity of our biology.

    The protein effect on SAD probably sums up all the bad press proteins and meat have been having since institutionalised nutrition science.

  • Andrea Romano

    I have been on keto for six months I lost 7 kg from 87 to 80 kg, I am 181 cm tall, but my triglycerides tripled from 90 to 270. How can it be possible?

  • H Browning

    Pigs have GI systems the most like humans.

  • beast shawnee

    Been a carnivore one month and a day! been Keto 2 additional weeks! Down 26.5 lbs…but the reason I am doing it is my auto-immune issues…I have Fibro-myalgia very seriously and have had it since I was born. I have thyroid issues, I have chronic anemia, and extreme allergies, plus asthma. My acid reflux has improved.

  • Ser, más que tener

    Surely all of this research collates back to our hunter gatherer primarily carnivore ancestors..
    They had to worry about saber tooth tigers..we've got forthcoming 5G smart cities to deal with

  • Ben Nguyen

    So the S.A.D. Insulin:Glucagon ratio of 4 represents someone who is in a fasted state, but has chronically elevated glucose due to diet? If so, what fasting glucose/insulin levels would predict how your I:G ratio will respond upon eating? Alternatively, is there any way to infer one's Insulin:Glucagon ratio (i.e. energy needs) after a meal since measuring directly doesn't seem probable?
    And is the issue with 'refeeding syndrome' that the metabolic costs required after eating, will pull more key nutrients from the already-depleted blood? If so, what should be the approach, plenty of salts/minerals with the meal?

    Also enjoyed the points about points about how erythrocyte (Red-Blood-Cells) don't have a mitochondria, and therefore can only use glucose for energy.. and Glucagon needs carnitine to transport fatty acids into the liver for the production of ketones!

  • Sinnergism

    A truly exceptional presentation!

    That was the clearest, and by far the best, explanation of protein's actual role in LCHF/ketogenic diets (and thus in the low-CHO/keto-adapted body) I've seen to date.

    I am in awe!

  • Theo Zodda

    Now a high fat diet is the 'healthy' diet? With respect, the idea that we haven't had an evolutionary adaptation to grains is asinine, furthermore you can clearly see it in physiology.

  • Sandip Paul

    this is awesome lecture. I have one doubt. we are focusing on producing more ketones but that can lead to ketoacidosis. Any idea how to avoid it.

  • kickn-aDead-cat

    It appears to me that if you go on a ketogenic diet purely for weight loss, then you don’t need that much extra protein. But if you’re on the ketogenic diet and you are exercising heavily, your muscles are going to demand more. Your muscles include your heart. And as you get older it’s even more necessary.

  • P K

    AFAIK the red blood cells, renal medulla and retina need glucose due to their mitochondrial deficiency, but their needs can be easily met by gluconeogenesis

  • CrumbleLives

    Interesting segment on ketogenesis. Carnitine I think is only needed to transport long chain fatty acids. Also if supplemented, it needs to be taken with simple carbs to increase its bioavailability to muscles.

  • Maryj

    Fruits and vegetables either are high oxalate (paradoxically low lectin) or if low oxalate then high in lectins. People have died from high oxalates and people become autoimmune with high lectin. Answer for these people, from an academic perspective is a carnivore diet.

  • Declan McArdle

    Fiddlesticks what your parents know, go back to what your grandparents knew.

  • andre adi

    19:30 70

  • Steven L.

    8:44 You'll be hard pressed to find a digestive system as similar to humans as canines. Nevertheless challenge it as you will.

    Me: *takes him up on his offer, types in "digestive system most similar to humans," finds pigs as the top result.

  • lowcarbkitchen

    Thank you! Good information and cleared up some things for me.

  • Josh Kamau

    Thats why zero-carb carnivore diet works….i guess

  • Angie Schneider

    1-2g protein / kg…Really? So I don't have to worry about eating 100gs of protein since I usually just have lower than 20gs of carbs?

  • Peter Cyr

    I love this guy. A real scientist on the right track. So generous with his time and efforts to help and so able to explain it clearly. This is the second stage of the revolution where professionals are taking over from the talented amatuers. A significant development.

  • Snapography

    Most sensible analysis of diet I have heard to date.

  • David Coomber

    Still not comfortable about the build up of Uric acid on a all meat diet so I tend to lean towards fat as the main benefactor of the success story of a no carb diet

  • bstylesk

    I like the doctor but he is talking googly Guk to me speak in layman's term not doctor terminology it is hard to stay on track with this guy

  • bstylesk

    I eat one meal a day my blood sugar keeps going up it takes two days of fasting to get my numbers down and low one hundreds I take a test it is 110 115 I eat it will go up 50 points from where I don't know what to do

  • Mikah Niehaus

    This is super interesting but can you please send my your study I want to go over it more

  • DiabloMinero

    Dogs have digestive systems like ours because dogs are wolves that we started feeding 10,000 years ago, and in the time since then the ones that were healthiest on our food had the most puppies.

  • whisperingsage

    I know Its common to label substances as antagonistic( insulin:glucagon, copper:zinc, etc) But I think of them.as.working as a team.

  • whisperingsage

    It's hard to find fat on meat in the store. The butcher's cut it off.

  • Dejan Atanackovic

    I am a bit late with this video.. But about 8 years ago, I had this very same information in my textbook.. "amino acids dramatically increase glucagon levels if there is no carbohydrate intake" .. And we don't update our textbooks so often here (Serbia) ..

  • Mark

    Interesting talk, but I would love to see him address IGF-1 and MTOR, and how higher Protein stimulates them. 😉

  • Bruce Lan

    thanks so much for the CHINESE TRADITIONAL subtitles <3

  • Emma alexander

    This is truly a great lecture. Well written, well spoken, great slides and science that makes sense to ever low carber consuming more than 15% protein. Love the low carb down under channel and definitely want to see Ben’s lecture this year. Bring it on!


    Dr. Benjamin Bikman – What about the APO-E-Gene? People with APO-E-4 will die if they eat "any" fat. Most of the population have the APO-E-3/4 Gene, which medical results state that we should eat a "low fat" diet. Then there is the APO-E-2 Gene. It's recommended that they eat completely different too.
    There are studies now, on "cancer" patients using a DNA test to see which APO-E-Gene they have. Do you know anything about this Gene? Should we all be getting a DNA test to see which # we have before we embark on a KETO diet or LCHF diet? This is very confusing & scary.

  • Amjed Abdeljelil

    Amazing Lecture Dr Benjamin..
    Love this Dr, I learned so much from
    his presentation..
    Thank you..

  • Larry Putra

    this guy is smart

  • Anne Summers

    Wonderful lecture. Thank you so much!

  • Pepe's bodega

    Bikmans presentations are so intresting

  • D Schulz

    Outstanding video

  • george hernandez

    aha moments!

  • tdreamgmail

    We do we want gluconeogenesis? I thought using protein for fuel was bad, ie using our muscles as glucose.

  • Peter Roach

    Easting green, leafy vegetable solves the problem of protein by products

  • Peter Roach

    Along with water of course.

  • NxZuRo Clan

    Est ce que quelqu’un peut me traduire en français ?? 🙏🙏🙏🙏

  • I I

    My body is not doing gluconeogenesis efficiently. I’m eating zero carbs and I keep getting hypoglycemia. What do I do

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